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In vitro maturation of oocytes in light of ovarian mitochondrial improvement: effectiveness and safety

Published online by Cambridge University Press:  02 July 2024

Nikos Petrogiannis ,
Kalliopi Chatzovoulou Open the ORCID record for Kalliopi Chatzovoulou [Opens in a new window] ,
Maria Filippa ,
Grigoris Grimbizis ,
Efstratios Kolibianakis  and
Katerina Chatzimeletiou Open the ORCID record for Katerina Chatzimeletiou [Opens in a new window]
Nikos Petrogiannis
Affiliation:
ART Unit, Naval Hospital of Athens, Athens, Greece
Kalliopi Chatzovoulou*
Affiliation:
ART Unit, Naval Hospital of Athens, Athens, Greece
Maria Filippa
Affiliation:
ART Unit, Naval Hospital of Athens, Athens, Greece
Grigoris Grimbizis
Affiliation:
Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Aristotle University Medical School, Papageorgiou General Hospital, Thessaloniki, Greece
Efstratios Kolibianakis
Affiliation:
Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Aristotle University Medical School, Papageorgiou General Hospital, Thessaloniki, Greece
Katerina Chatzimeletiou
Affiliation:
Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Aristotle University Medical School, Papageorgiou General Hospital, Thessaloniki, Greece
*
Corresponding author: Kalliopi Chatzovoulou; Email: kchatzovoulou@icloud.com
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Summary

In vitro maturation of oocytes (IVM) represents an assisted reproductive technique that involves the minimal or absence of ovarian stimulation and is beneficial to specific groups of patients. These may include women with polycystic ovarian syndrome and/or patients who need a fertility preservation option before undergoing gonadotoxic treatment. However, when IVM is applied in cases where it is not recommended, it can be considered as an add-on technique, as described by the ESHRE Guideline Group on Female Fertility Preservation. Interestingly, IVM has not been proven yet to be as effective as conventional IVF in the laboratory, in terms of clinical pregnancy and live birth rates, while concerns have been raised for its long-term safety. As a result, both safety and efficacy of IVM remain still questionable and additional data are needed to draw conclusions.

Keywords

clinical pregnancyIn vitro maturation (IVM)live birth ratemitochondriaoocytesafety
Type
Review Article
Information
Zygote , Volume 32 , Issue 3 , June 2024 , pp. 183 - 189
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Copyright
© The Author(s), 2024. Published by Cambridge University Press

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