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Paternal Age and ART

Key Points		see Q&A
84	The AR was almost constant at < 50% until the age of 35 but increased steadily to reach > 90% at 44.
85	In terms of the man’s age, the NON-adjusted analysis revealed a correlation with AR.
86	After correcting for the woman’s age, no correlation was observed between the mans age and the rate of aneuploidy.
87	Advanced paternal age does not carry an increased risk of aneuploidy for the embryo and does not in itself constitute an indication for PGT-A
204	Men over 51 years of age have a higher miscarriage rate compared to men under 35 years in oocyte recipient cycles.
205	Men over 51 years of age have a lower pregnancy rate compared to men under 35 years in oocyte recipient cycles.

	TextBook
	Advanced Paternal Age in Focus: Unraveling Its Influence on Assisted Reproductive Technology Outcomes
	DOI:10.3390/jcm13102731 by Journal of Clinical Medicine in 2024			[883]
	The other face of advanced paternal age: a scoping review of its terminological, social, public health, psychological, ethical and regulatory aspects
	DOI:10.1093/humupd/dmaa046 by Human Reproduction Update in 2021			[417]
	Impact of paternal age on assisted reproductive technology outcomes and offspring health: a systematic review
	DOI:10.1111/andr.13385 by Andrology. in 0			[260]

	Recent Publications
	Increased paternal age adversely affects live birth rates in oocyte recipient cycles
	DOI:10.1080/14647273.2025.2506799 by Human Fertility (Camb). in 2025			[2738]
	Influence of parental age on chromosomal abnormalities in PGT-A embryos: exponentially increasing in the mother and completely null in the father
	DOI:10.1007/s10815-025-03462-0 by Journal of Assisted Reproduction and Genetics in 2025			[2665]
	Effect of paternal age on clinical outcomes of in vitro fertilization-embryo transfer cycles
	DOI:10.3389/fendo.2024.1325523 by Frontiers in Endocrinology (Lausanne) in 2024			[1949]
	High risk of low birth weight in couples with advanced paternal age in in vitro fertilization treatment
	DOI:10.1111/andr.13745 by Andrology. in 2024			[1808]

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