Preimplantation genetic testing: A narrative review
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On the origins and fate of chromosomal abnormalities in human preimplantation embryos: an unsolved riddle
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Systematic review and meta-analysis: does pre-implantation genetic testing for aneuploidy at the blastocyst stage improve live birth rate?
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Aligning genotyping and copy number data in single trophectoderm biopsies for aneuploidy prediction: uncovering incomplete concordance
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Novel embryo selection strategies-finding the right balance
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Impact of blastocyst biopsy and comprehensive chromosome screening technology on preimplantation genetic screening: a systematic review of randomized controlled trials
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Past, Present, and Future Strategies for Enhanced Assessment of Embryo's Genome and Reproductive Competence in Women of Advanced Reproductive Age
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Preimplantation Genetic Testing for Aneuploidy in In Vitro Fertilization Using Comprehensive Chromosome Screening: A Systematic Review and Meta-Analysis
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Advancements and Applications of Preimplantation Genetic Testing in In Vitro Fertilization: A Comprehensive Review
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The cytogenetic constitution of human blastocysts: insights from comprehensive chromosome screening strategies
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Identifying parental and cell-division origins of aneuploidy in the human blastocyst
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On the reproductive capabilities of aneuploid human preimplantation embryos
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Unpacking the artificial intelligence toolbox for embryo ploidy prediction.
DOI:10.1093/humrep/dead223 by Human Reproduction in 2023
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Blastocyst quality and reproductive and perinatal outcomes: a multinational multicentre observational study.
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Obstetrical and neonatal outcomes from the BEST Trial: single embryo transfer with aneuploidy screening improves outcomes after in vitro fertilization without compromising delivery rates
DOI:/10.1016/j.ajog.2013.10.016 by American Journal of Obstetrics & Gynecology in 2014
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Impact of trophectoderm biopsy for preimplantation genetic testing on obstetric and neonatal outcomes: a meta-analysis
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Trophectoderm non-coding RNAs reflect the higher metabolic and more invasive properties of young maternal age blastocysts
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Can trophectoderm RNA analysis predict human blastocyst competency?
DOI:10.1080/19396368.2019.1625085 by Systems Biology in Reproductive Medicine in 2019
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A systematic review and meta-analysis: clinical outcomes of recurrent pregnancy failure resulting from preimplantation genetic testing for aneuploidy
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Origins and mechanisms leading to aneuploidy in human eggs.
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Parental Balanced Translocation Carriers do not have Decreased Usable Blastulation Rates or Live Birth Rates Compared to Infertile Controls
DOI:10.1016/j.fertnstert.2024.11.010 by Fertility and Sterility in 2024
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Feasibility of preimplantation genetic testing for aneuploidy on frozen-thawed embryos following conventional IVF insemination
DOI:10.3389/fendo.2024.1441014 by Frontiers in Endocrinology (Lausanne) in 2024
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Healthy live births achieved from embryos diagnosed as non-mosaic segmental aneuploid
DOI:10.1007/s10815-024-03282-8 by Journal of Assisted Reproduction and Genetics in 2024
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Meiotic and mitotic aneuploidies drive arrest of in vitro fertilized human preimplantation embryos
DOI:10.1186/s13073-023-01231-1 by Genome Medicine in 2024
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Incidence of haploidy and triploidy in trophectoderm biopsies of blastocysts derived from normally and abnormally fertilized oocytes
DOI:10.1007/s10815-024-03278-4 by Journal of Assisted Reproduction and Genetics in 2024
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Chromosome segregation of human nonhomologous Robertsonian translocations: insights from preimplantation genetic testing
DOI:10.1038/s41431-024-01693-w by European journal of human genetics in 2024
[2056]
Aligning genotyping and copy number data in single trophectoderm biopsies for aneuploidy prediction: uncovering incomplete concordance
DOI:10.1093/hropen/hoae056 by Human Reproduction Open in 2024
[2035]
Routine detection of consanguinity through preimplantation genetic testing in human embryos
DOI:10.1016/j.rbmo.2024.104453 by Reproductive BioMedicine Online in 2024
[2030]
Human embryos harbor complex mosaicism with broad presence of aneuploid cells during early development
DOI:10.1038/s41421-024-00719-3 by Cell Discovery in 2024
[2014]
Correlation between high FSH levels and increased risk of aneuploidy: the origin of the hypothesis
DOI:10.1093/molehr/gaae028 by Molecular Human Reproduction in 2024
[2003]
Differences in preimplantation blastocyst chromosomal aberrations between polycystic ovary syndrome women and controls: a multi-center retrospective cohort study
DOI:10.1007/s10815-024-03235-1 by Journal of Assisted Reproduction and Genetics in 2024
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Embryonic genome instability upon DNA replication timing program emergence
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Comparison of aneuploidy for patients of different ages treated with progestin-primed ovarian stimulation or GnRH antagonist protocols
DOI:10.1016/j.rbmo.2024.104349 by Reproductive BioMedicine Online in 2024
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Preimplantation Genetic Testing Inhibits the Transmission of Pathogenic Variants Associated With Cerebral White Matter Disease
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Evaluating the Plausibility of Euploid Embryos Transfer on Day-5 by Reanalysis of Day-3 Single Aneuploid Embryos: A Case Series
DOI:10.18502/jri.v25i1.15200 by Journal of Reproduction and Infertility in 2024
[1717]
Embryonic aneuploidy – the true “last barrier in assisted reproductive technology”?
DOI:10.1016/j.xfss.2024.08.002 by F&S Science in 2024
[1682]
Blastocoel fluid as an alternative source of DNA for minimally invasive PGT and biomarker of embryo competence
DOI:10.1016/j.rbmo.2024.104322 by Reproductive BioMedicine Online in 2024
[1651]
Aneuploidy rates and likelihood of obtaining a usable embryo for transfer among IVF cycles using PGT-M+PGT-A compared with IVF cycles using PGT-A alone
DOI:10.1016/j.fertnstert.2024.07.030 by Fertility and Sterility in 2024
[1524]
Trophectoderm biopsy is associated with lower risks of moderate to extreme prematurity and low birthweights - a national registry cohort study of singleton live births from frozen-thawed blastocyst transfers
DOI:10.1016/j.ajog.2024.07.007 by American Journal of Obstetrics & Gynecology in 2024
[1442]
Basal FSH values are positively associated with aneuploidy incidence in pre-advanced maternal age (AMA) but not in AMA patients
DOI:10.1007/s10815-024-03190-x by Journal of Assisted Reproduction and Genetics in 2024
[1384]
Preimplantation genetic testing: A narrative review
DOI:10.1097/j.pbj.0000000000000262 by Porto Biomedical Journal in 2024
[1379]
Fetus Conceived via In Vitro Fertilization With Mosaic Uniparental Isodisomy and Two Balanced Translocations
DOI:10.7759/cureus.62095 by Cureus. in 2024
[1369]
Preimplantation Genetic Testing for Aneuploidy in In Vitro Fertilization Using Comprehensive Chromosome Screening: A Systematic Review and Meta-Analysis
DOI:10.22074/ijfs.2023.1996379.1450 by International Journal of Fertility & Sterility in 2024
[1331]
Updates in preimplantation genetic testing (PGT)
DOI:10.1016/j.bpobgyn.2024.102526 by Best Practice & Research Clinical Endocrinology & Metabolism in 2024
[1286]
Mapping of long interspersed element-1 (L1) insertions by TIPseq provides information about sub chromosomal genetic variation in human embryos
DOI:10.1007/s10815-024-03176-9 by Journal of Assisted Reproduction and Genetics in 2024
[1279]
Assessing the necessity of screening ≤5 Mb segmental aneuploidy in routine PGT for aneuploidies
DOI:10.1016/j.rbmo.2024.103991 by Reproductive BioMedicine Online in 2024
[1237]
Polygenic embryo screening: quo vadis?
DOI:10.1007/s10815-024-03169-8 by Journal of Assisted Reproduction and Genetics in 2024
[1154]
Webinars
Challenges in Decision Making During PGT [Progenesis Academy]
Progenesis Academy
PGT-A Overview - [Progenesis Academy]
Progenesis Academy
PGT-Complete: A new standard of care to reduce anxiety and increase transfer opportunity
Cooper Surgical
Live from PGDIS with our genomics experts
Cooper Surgical
Sub topics related to :Genetic analysis of the embryo.
ID
Course
Cleavage-stage human embryo arrest
Embryo attrition in planned PGT-A
Euploidy rates
Hyperspectral autofluorescence microscopy and PGD
Impact of trophoectoderm biopsy
Management of Mosaic Embryos +
References related to SubTopic
Zhang YX, Chen JJ, Nabu S, et al. The Pregnancy Outcome of Mosaic Embryo Transfer: A Prospective Multicenter Study and Meta-Analysis. Genes (Basel). 2020,11(9):E973. Published 2020 Aug 21. doi:10.3390/genes11090973 - ID:2708
Palmerola KL, Vitez SF, Amrane S, Fischer CP, Forman EJ. Minimizing mosaicism: assessing the impact of fertilization method on rate of mosaicism after next-generation sequencing (NGS) preimplantation genetic testing for aneuploidy (PGT-A). J Assist Reprod Genet. 2019,36(1):153-157. doi:10.1007/s10815-018-1347-6 - ID:2709
Popovic M, Dhaenens L, Taelman J, et al. Extended in vitro culture of human embryos demonstrates the complex nature of diagnosing chromosomal mosaicism from a single trophectoderm biopsy. Hum Reprod. 2019,34(4):758-769. doi:10.1093/humrep/dez012 - ID:2710
Fragouli E, Alfarawati S, Spath K, et al. Analysis of implantation and ongoing pregnancy rates following the transfer of mosaic diploid-aneuploid blastocysts. Hum Genet. 2017,136(7):805-819. doi:10.1007/s00439-017-1797-4 - ID:2711
Maxwell SM, Grifo JA. Should every embryo undergo preimplantation genetic testing for aneuploidy? A review of the modern approach to in vitro fertilization. Best Pract Res Clin Obstet Gynaecol. 2018,53:38-47. doi:10.1016/j.bpobgyn.2018.07.005 - ID:2712
Chan YM, Li TC, Poon LCY. Impact of preimplantation genetic testing for aneuploidy on obstetrical practice. Curr Opin Obstet Gynecol. 2019,31(2):127-131. doi:10.1097/GCO.0000000000000521 - ID:2713
Bolton, H., Graham, S., Van der Aa, N. et al. Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential. Nat Commun 7, 11165 (2016). https://doi.org/10.1038/ncomms11165 - ID:2714
Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential - Figure 7: Effects of pre-implantation chromosome mosaicism on embryo development and survival. https://www.nature.com/articles/ncomms11165/figures/7 - ID:2715
Alksere B, Grinfelde I, Kornejeva L, Dzalbs A, Vedmedovska N, Kovalova I, Conka U, Andersone S, Krasucka S, Blumberga A, Berzina D, Fodina V. The outcomes after transfers of embryos with chromosomal mosaicism: a single reproductive medicine center experience at iVF Riga clinic. Gynecol Endocrinol. 2020,36(sup1):53-57. doi: 10.1080/09513590.2020.1816719 - ID:2961
Gleicher N, Barad DH, Ben-Rafael Z, Glujovsky D, Mochizuki L, Modi D, Murtinger M, Patrizio P, Orvieto R, Takahashi S, Weghofer A, Ziebe S, International Do No Harm Group in IVF (IDNHG-IVF). Commentary on two recently published formal guidelines on management of "mosaic" embryos after preimplantation genetic testing for aneuploidy (PGT-A). Reprod Biol Endocrinol. 2021,19(1):23. doi:10.1186/s12958- - ID:3181
Viotti M, Victor AR, Barnes FL, Zouves CG, Besser AG, Grifo JA, Cheng EH, Lee MS, Horcajadas JA, Corti L, Fiorentino F, Spinella F, Minasi MG, Greco E, Munné S. Using outcome data from one thousand mosaic embryo transfers to formulate an embryo ranking system for clinical use. Fertil Steril. 2021 Mar 5:S0015-0282(20)32716-3. doi: 10.1016/j.fertnstert.2020.11.041 - ID:3208
Eggenhuizen GM, Go A, Koster MPH, Baart EB, Galjaard RJ. Confined placental mosaicism and the association with pregnancy outcome and fetal growth: a review of the literature. Hum Reprod Update. 2021 May 13:dmab009. doi: 10.1093/humupd/dmab009 - ID:3386
Mourad A, Antaki R, Bissonnette F, Al Baini O, Saadeh B, Jamal W. Evidence-based clinical prioritization of embryos with mosaic results: a systematic review and meta-analysis. J Assist Reprod Genet. 2021 Sep 2. doi: 10.1007/s10815-021-02279-x - ID:3922
Eggenhuizen GM, Go A, Koster MPH, Baart EB, Galjaard RJ. Confined placental mosaicism and the association with pregnancy outcome and fetal growth: a review of the literature. Hum Reprod Update. 2021 Aug 20,27(5):885-903. doi: 10.1093/humupd/dmab009 - ID:3923
Viotti M, McCoy RC, Griffin DK, Spinella F, Greco E, Madjunkov M, Madjunkova S, Librach CL, Victor AR, Barnes FL, Zouves CG. Let the data do the talking: the need to consider mosaicism during embryo selection. Fertil Steril. 2021 Nov,116(5):1212-1219. doi: 10.1016/j.fertnstert.2021.09.008 - ID:3924
Capalbo A, Poli M, Rienzi L, et.al Mosaic human preimplantation embryos and their developmental potential in a prospective, non-selection clinical trial. Am J Hum Genet. 2021 Nov 11:S0002-9297(21)00412-2. doi: 10.1016/j.ajhg.2021.11.002 - ID:3965
Leigh D, Cram DS, Rechitsky S, Handyside A, Wells D, Munne S, Kahraman S, Grifo J, Katz-Jaffe M, Rubio C, Viotti M, Forman E, Xu K, Gordon T, Madjunkova S, Qiao J, Chen ZJ, Harton G, Gianaroli L, Simon C, Scott R, Simpson JL, Kuliev A. PGDIS position statement on the transfer of mosaic embryos 2021. Reprod Biomed Online. 2022 Mar 20:S1472-6483(22)00150-X. doi: 10.1016/j.rbmo.2022.03.013 - ID:4395
Huang QX, Wang ZH, Huang WJ, Mao LH, Lin CL, Chen GY, Wang CX, Chen ZB, Lin YL, He LY, Liu Y. Factors influencing mosaicism: a retrospective analysis. Reprod Biomed Online. 2022 May 6:S1472-6483(22)00295-4. doi: 10.1016/j.rbmo.2022.04.020 - ID:4444
