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Embryo multinucleation: detection, possible origins, and implications for treatment
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Developmental plasticity and its relevance to assisted human reproduction
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Early embryo ontogeny and parental genetic legacy: from developmental mechanisms to diagnosis and treatment
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High proportion of zygotes with multiple pronuclei increase the embryo multinucleation rate during conventional IVF
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Regulation of glucose metabolism: Effects on oocyte, preimplantation embryo, assisted reproductive technology and embryonic stem cell
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Temporal variability and cell mechanics control robustness in mammalian embryogenesis
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Embryo multinucleation: detection, possible origins, and implications for treatment
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Micronuclei in 2-cell embryos show higher blastocyst formation rates on human embryonic development
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An aggregated mitochondrial distribution in preimplantation embryos disrupts nuclear morphology, function, and developmental potential
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Metabolic regulation of preimplantation embryo development in vivo and in vitro: Molecular mechanisms and insights
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Provision of choline chloride to the bovine preimplantation embryo alters postnatal body size and DNA methylation,
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Webinars
CELLF CONTROL - I3 SESSION 126
The International IVF Initiative - i3
THE MINISTRY OF EMBRYOLOGY AND IMPLANTATION: DYNAMICS OF EMBRYO DEVELOPMENT I
The International IVF Initiative - i3
Sub topics related to :Embryo Development
ID
Course
Apicobasal RNA asymmetries control blastomere fate
Cleavage-stage human embryo arrest
Dynamics of embryo development
Elevated Progesterone Levels on the Day of hCG
Embryo quality and blastocyst collapse and contractions+
Growth Factors and Embryo development+
Human embryonic genome activation
Management of Mosaic Embryos +
References related to SubTopic
Zhang YX, Chen JJ, Nabu S, et al. The Pregnancy Outcome of Mosaic Embryo Transfer: A Prospective Multicenter Study and Meta-Analysis. Genes (Basel). 2020,11(9):E973. Published 2020 Aug 21. doi:10.3390/genes11090973 - ID:2708
Palmerola KL, Vitez SF, Amrane S, Fischer CP, Forman EJ. Minimizing mosaicism: assessing the impact of fertilization method on rate of mosaicism after next-generation sequencing (NGS) preimplantation genetic testing for aneuploidy (PGT-A). J Assist Reprod Genet. 2019,36(1):153-157. doi:10.1007/s10815-018-1347-6 - ID:2709
Popovic M, Dhaenens L, Taelman J, et al. Extended in vitro culture of human embryos demonstrates the complex nature of diagnosing chromosomal mosaicism from a single trophectoderm biopsy. Hum Reprod. 2019,34(4):758-769. doi:10.1093/humrep/dez012 - ID:2710
Fragouli E, Alfarawati S, Spath K, et al. Analysis of implantation and ongoing pregnancy rates following the transfer of mosaic diploid-aneuploid blastocysts. Hum Genet. 2017,136(7):805-819. doi:10.1007/s00439-017-1797-4 - ID:2711
Maxwell SM, Grifo JA. Should every embryo undergo preimplantation genetic testing for aneuploidy? A review of the modern approach to in vitro fertilization. Best Pract Res Clin Obstet Gynaecol. 2018,53:38-47. doi:10.1016/j.bpobgyn.2018.07.005 - ID:2712
Chan YM, Li TC, Poon LCY. Impact of preimplantation genetic testing for aneuploidy on obstetrical practice. Curr Opin Obstet Gynecol. 2019,31(2):127-131. doi:10.1097/GCO.0000000000000521 - ID:2713
Bolton, H., Graham, S., Van der Aa, N. et al. Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential. Nat Commun 7, 11165 (2016). https://doi.org/10.1038/ncomms11165 - ID:2714
Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential - Figure 7: Effects of pre-implantation chromosome mosaicism on embryo development and survival. https://www.nature.com/articles/ncomms11165/figures/7 - ID:2715
Alksere B, Grinfelde I, Kornejeva L, Dzalbs A, Vedmedovska N, Kovalova I, Conka U, Andersone S, Krasucka S, Blumberga A, Berzina D, Fodina V. The outcomes after transfers of embryos with chromosomal mosaicism: a single reproductive medicine center experience at iVF Riga clinic. Gynecol Endocrinol. 2020,36(sup1):53-57. doi: 10.1080/09513590.2020.1816719 - ID:2961
Gleicher N, Barad DH, Ben-Rafael Z, Glujovsky D, Mochizuki L, Modi D, Murtinger M, Patrizio P, Orvieto R, Takahashi S, Weghofer A, Ziebe S, International Do No Harm Group in IVF (IDNHG-IVF). Commentary on two recently published formal guidelines on management of "mosaic" embryos after preimplantation genetic testing for aneuploidy (PGT-A). Reprod Biol Endocrinol. 2021,19(1):23. doi:10.1186/s12958- - ID:3181
Viotti M, Victor AR, Barnes FL, Zouves CG, Besser AG, Grifo JA, Cheng EH, Lee MS, Horcajadas JA, Corti L, Fiorentino F, Spinella F, Minasi MG, Greco E, Munné S. Using outcome data from one thousand mosaic embryo transfers to formulate an embryo ranking system for clinical use. Fertil Steril. 2021 Mar 5:S0015-0282(20)32716-3. doi: 10.1016/j.fertnstert.2020.11.041 - ID:3208
Eggenhuizen GM, Go A, Koster MPH, Baart EB, Galjaard RJ. Confined placental mosaicism and the association with pregnancy outcome and fetal growth: a review of the literature. Hum Reprod Update. 2021 May 13:dmab009. doi: 10.1093/humupd/dmab009 - ID:3386
Mourad A, Antaki R, Bissonnette F, Al Baini O, Saadeh B, Jamal W. Evidence-based clinical prioritization of embryos with mosaic results: a systematic review and meta-analysis. J Assist Reprod Genet. 2021 Sep 2. doi: 10.1007/s10815-021-02279-x - ID:3922
Eggenhuizen GM, Go A, Koster MPH, Baart EB, Galjaard RJ. Confined placental mosaicism and the association with pregnancy outcome and fetal growth: a review of the literature. Hum Reprod Update. 2021 Aug 20,27(5):885-903. doi: 10.1093/humupd/dmab009 - ID:3923
Viotti M, McCoy RC, Griffin DK, Spinella F, Greco E, Madjunkov M, Madjunkova S, Librach CL, Victor AR, Barnes FL, Zouves CG. Let the data do the talking: the need to consider mosaicism during embryo selection. Fertil Steril. 2021 Nov,116(5):1212-1219. doi: 10.1016/j.fertnstert.2021.09.008 - ID:3924
Capalbo A, Poli M, Rienzi L, et.al Mosaic human preimplantation embryos and their developmental potential in a prospective, non-selection clinical trial. Am J Hum Genet. 2021 Nov 11:S0002-9297(21)00412-2. doi: 10.1016/j.ajhg.2021.11.002 - ID:3965
Leigh D, Cram DS, Rechitsky S, Handyside A, Wells D, Munne S, Kahraman S, Grifo J, Katz-Jaffe M, Rubio C, Viotti M, Forman E, Xu K, Gordon T, Madjunkova S, Qiao J, Chen ZJ, Harton G, Gianaroli L, Simon C, Scott R, Simpson JL, Kuliev A. PGDIS position statement on the transfer of mosaic embryos 2021. Reprod Biomed Online. 2022 Mar 20:S1472-6483(22)00150-X. doi: 10.1016/j.rbmo.2022.03.013 - ID:4395
Huang QX, Wang ZH, Huang WJ, Mao LH, Lin CL, Chen GY, Wang CX, Chen ZB, Lin YL, He LY, Liu Y. Factors influencing mosaicism: a retrospective analysis. Reprod Biomed Online. 2022 May 6:S1472-6483(22)00295-4. doi: 10.1016/j.rbmo.2022.04.020 - ID:4444
Maternal-to-zygotic transition (MZT) and embryo development and arrest.
Mitochondria and IVF Outcome
Mitochondrial DNA and ART outcome
Paternal RNA and embryonic genome activation (EGA)
