In IVF-generated embryos, the proteome was more sensitive to high oxygen levels than the global metabolomic profile.
214
In IVF-generated embryos at high oxygen levels, enzymes involved in splicing and the spliceosome are altered.
215
In IVF-generated embryos at high oxygen levels, numerous metabolic pathways, particularly amino acids metabolism, are altered.
216
In IVF-generated embryos at high oxygen levels, there is activation of the integrated stress response (ISR) and downregulation of mTOR pathways.
ClassRoom
Oxidative stress and ovarian aging: from cellular mechanisms to diagnostics and treatment.
DOI:10.1093/humrep/deae082 by Human Reproduction in 2024
[904]
DNA damage and repair in the female germline: contributions to ART.
DOI:10.1093/humupd/dmy040 by Human Reproduction Update in 2019
[77]
DNA damage and repair in human oocytes and embryos: a review.
DOI:10.1017/S0967199410000286 by Zygote. in 2010
[76]
TextBook
Effects of Supplementation with Natural Antioxidants on Oocytes and Preimplantation Embryos.
DOI:10.3390/antiox9070612 by Antioxidants in 2020
[454]
Oxidative Stress and Assisted Reproduction: A Comprehensive Review of Its Pathophysiological Role and Strategies for Optimizing Embryo Culture Environment.
DOI:10.3390/antiox11030477 by Antioxidants in 2022
[33]
Recent Publications
Proteomic and metabolomic insights into oxidative stress response activation in mouse embryos generated by in vitro fertilization
DOI:10.1093/hropen/hoaf022 by Human Reproduction Open in 2025
[2743]
Oxidative stress and ovarian aging: from cellular mechanisms to diagnostics and treatment.
DOI:10.1093/humrep/deae082 by Human Reproduction in 2024
[992]
Webinars
Session 69: The embryo in culture: Imprinting, oxidative stress and epigentic changes. [II3]
